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KMID : 0811719980020020201
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Korean Journal of Physiology & Pharmacology
1998 Volume.2 No. 2 p.201 ~ p.207
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Inhibitory Effects of Ginseng Saponins on c-fos mRNA Expression and the Proliferation of Rat Aortic Vascular Smooth Muscle Cells Stimulated by Angiotensin Ⅱ
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Woong Choi
Jin Young Jung/Hun Sik Kim/Hee Yul Ahn/Yeo Pyo Yun/Jong Dae Park
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Abstract
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To evaluate the possibility that the ginseng saponins could be developed as an anti-arteriosclerotic agent, we examined the inhibitory effects of ginseng saponins (total saponin[TS], panaxatriol[PT], panaxadiol[PD]) on the expression of c-fos mRNA and the proliferation of cultured rat aortic vascular smooth muscle cells (VSMCs) stimulated by angiotensin II (Ang II). TS and PT (1.0 mg/ml) suppressed c-fos mRNA induction in VSMCs stimulated by 10?5 M Ang II. The order of inhibitory potency was PT>TS. Ginseng saponins (0.01∼1.0 mg/ml) inhibited the proliferation of VSMCs stimulated by Ang II in a concentration dependent manner, the inhibitory potency was TS＞PT＞PD at 0.1∼1.0 mg/ml. These results suggest that ginseng saponins may suppress Ang II-stimulated proliferation of aortic VSMCs which can be seen in atherosclerosis, hypertension and restenosis.
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KEYWORD
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Ginseng saponins, c-fos, Proliferation, Angiotensin Ⅱ, Vascular smooth muscle cells,
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